5J4B

Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution

This is a non-PDB format compatible entry.

Summary for 5J4B

• Entry DOI: 10.2210/pdb5j4b/pdb
• Related: 5J4C
• Descriptor: 23S ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• Functional Keywords: ribosome, cisplatin, anticancer drug, cytotoxicity, inhibition of translation, translocation, mrna channel, gtpase activating center
• Biological source: Escherichia coli; More
• Total number of polymer chains: 112
• Total formula weight: 4580570.97

Authors

Melnikov, S.V.,Soll, D.,Steitz, T.A.,Polikanov, Y.S. (deposition date: 2016-03-31, release date: 2016-04-27, Last modification date: 2023-11-15)

• Primary citation: Melnikov, S.V.,Soll, D.,Steitz, T.A.,Polikanov, Y.S.; Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.; Nucleic Acids Res., 44:4978-4987, 2016; PubMed: 27079977; DOI: 10.1093/nar/gkw246

Experimental method

X-RAY DIFFRACTION (2.6 Å)