5DK3
Crystal Structure of Pembrolizumab, a full length IgG4 antibody
Summary for 5DK3
Entry DOI | 10.2210/pdb5dk3/pdb |
Related PRD ID | PRD_900003 |
Descriptor | Light Chain, Heavy Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | cancer, antibody, subclasses, igg4, melanoma, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 149953.56 |
Authors | Scapin, G.,Prosise, W.,Reichert, P. (deposition date: 2015-09-02, release date: 2015-11-18, Last modification date: 2020-07-29) |
Primary citation | Scapin, G.,Yang, X.,Prosise, W.W.,McCoy, M.,Reichert, P.,Johnston, J.M.,Kashi, R.S.,Strickland, C. Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab. Nat.Struct.Mol.Biol., 22:953-958, 2015 Cited by PubMed: 26595420DOI: 10.1038/nsmb.3129 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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