5CTV
Catalytic domain of LytA, the major autolysin of Streptococcus pneumoniae, (C60A, H133A, C136A mutant) complexed with peptidoglycan fragment
Summary for 5CTV
Entry DOI | 10.2210/pdb5ctv/pdb |
Related | 4IVV |
Descriptor | Autolysin, fragment of peptidoglycan, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-methyl 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-beta-D-glucopyranoside-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-methyl 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | lyta, pneumococci, autolysis, amidase, peptidoglycan complex, antibiotics, hydrolase |
Biological source | Streptococcus pneumoniae serotype 4 More |
Cellular location | Secreted : P06653 |
Total number of polymer chains | 3 |
Total formula weight | 23181.31 |
Authors | Achour, A.,Sandalova, T.,Mellroth, P. (deposition date: 2015-07-24, release date: 2016-06-15, Last modification date: 2024-01-10) |
Primary citation | Sandalova, T.,Lee, M.,Henriques-Normark, B.,Hesek, D.,Mobashery, S.,Mellroth, P.,Achour, A. The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity. Mol.Microbiol., 101:954-967, 2016 Cited by PubMed: 27273793DOI: 10.1111/mmi.13435 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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