5CSZ
CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11
Summary for 5CSZ
Entry DOI | 10.2210/pdb5csz/pdb |
Descriptor | GANTENERUMAB FAB FRAGMENT HEAVY CHAIN, GANTENERUMAB FAB FRAGMENT LIGHT CHAIN, Amyloid beta A4 protein, ... (6 entities in total) |
Functional Keywords | antibody, alzheimer, abeta, gantenerumab, gant_abeta_1_11 09-a, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 98421.40 |
Authors | Benz, J.,Burger, D.,Loetscher, H.R.,Bohrmann, B. (deposition date: 2015-07-23, release date: 2015-08-12, Last modification date: 2020-07-29) |
Primary citation | Bohrmann, B.,Baumann, K.,Benz, J.,Gerber, F.,Huber, W.,Knoflach, F.,Messer, J.,Oroszlan, K.,Rauchenberger, R.,Richter, W.F.,Rothe, C.,Urban, M.,Bardroff, M.,Winter, M.,Nordstedt, C.,Loetscher, H. Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-Beta binding and elicits cell-mediated removal of human amyloid-Beta. J. Alzheimers Dis., 28:49-69, 2012 Cited by PubMed: 21955818DOI: 10.3233/JAD-2011-110977 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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