4ZY3

Crystal Structure of Keap1 in Complex with a small chemical compound, K67

Summary for 4ZY3

• Entry DOI: 10.2210/pdb4zy3/pdb
• Descriptor: Kelch-like ECH-associated protein 1, FORMIC ACID, N,N'-[2-(2-oxopropyl)naphthalene-1,4-diyl]bis(4-ethoxybenzenesulfonamide), ... (4 entities in total)
• Functional Keywords: nrf2, keap1, stress sensor, small molecule binding, double glycine repeat, kelch domain, p62, transcription
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 69797.64

Authors

Fukutomi, T.,Iso, T.,Suzuki, T.,Takagi, K.,Mizushima, T.,Komatsu, M.,Yamamoto, M. (deposition date: 2015-05-21, release date: 2016-05-25, Last modification date: 2023-11-08)

• Primary citation: Saito, T.,Ichimura, Y.,Taguchi, K.,Suzuki, T.,Mizushima, T.,Takagi, K.,Hirose, Y.,Nagahashi, M.,Iso, T.,Fukutomi, T.,Ohishi, M.,Endo, K.,Uemura, T.,Nishito, Y.,Okuda, S.,Obata, M.,Kouno, T.,Imamura, R.,Tada, Y.,Obata, R.,Yasuda, D.,Takahashi, K.,Fujimura, T.,Pi, J.,Lee, M.S.,Ueno, T.,Ohe, T.,Mashino, T.,Wakai, T.,Kojima, H.,Okabe, T.,Nagano, T.,Motohashi, H.,Waguri, S.,Soga, T.,Yamamoto, M.,Tanaka, K.,Komatsu, M.; p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming; Nat Commun, 7:12030-12030, 2016; PubMed: 27345495; DOI: 10.1038/ncomms12030

Experimental method

X-RAY DIFFRACTION (1.8 Å)