4ZX3

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10b

Summary for 4ZX3

Entry DOI	10.2210/pdb4zx3/pdb
Related	3EBG 4ZW3 4ZW5 4ZW6 4ZW7 4ZW8 4ZX4 4ZX5 4ZX6
Descriptor	M1 family aminopeptidase, ZINC ION, N-[(1R)-1-(4-bromophenyl)-2-(hydroxyamino)-2-oxoethyl]-2,2-dimethylpropanamide, ... (6 entities in total)
Functional Keywords	m1 alanyl-aminopeptidase, protease, inhibitor, hydroxamic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum
Total number of polymer chains	1
Total formula weight	104360.19
Authors	Drinkwater, N.,McGowan, S. (deposition date: 2015-05-20, release date: 2016-03-30, Last modification date: 2023-09-27)
Primary citation	Drinkwater, N.,Vinh, N.B.,Mistry, S.N.,Bamert, R.S.,Ruggeri, C.,Holleran, J.P.,Loganathan, S.,Paiardini, A.,Charman, S.A.,Powell, A.K.,Avery, V.M.,McGowan, S.,Scammells, P.J. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110:43-64, 2016 Cited by PubMed: 26807544 DOI: 10.1016/j.ejmech.2016.01.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation