4ZX0

Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor

Summary for 4ZX0

Entry DOI	10.2210/pdb4zx0/pdb
Related	4ZWI 4ZWX 4ZWY 4ZWZ 4ZX1
Descriptor	Carbonic anhydrase 2, ZINC ION, methyl (2S,4R)-1-[(2S,3R,4R,5S,6S)-6-(acetyloxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfonyl-4-sulfamoyloxy-pyrrolidine-2-carb oxylate, ... (5 entities in total)
Functional Keywords	carbonic anhydrase ii, glucosyl sulfamate, inhibitor complex., lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29582.62
Authors	Mahon, B.P.,Lomelino, C.L.,Pinard, M.A.,McKenna, R. (deposition date: 2015-05-19, release date: 2015-10-28, Last modification date: 2024-03-06)
Primary citation	Mahon, B.P.,Lomelino, C.L.,Moeker, J.,Rankin, G.M.,Driscoll, J.M.,Salguero, A.L.,Pinard, M.A.,Vullo, D.,Supuran, C.T.,Poulsen, S.A.,McKenna, R. Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX using Structure-Activity Relationships of Glucosyl-Based Sulfamates J. Med. Chem., 58:6630-6638, 2015 Cited by PubMed: 26203869 DOI: 10.1021/acs.jmedchem.5b00845 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation