4ZQL
Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide inhibitor
4ZQL の概要
エントリーDOI | 10.2210/pdb4zql/pdb |
分子名称 | Transcription intermediary factor 1-alpha, ZINC ION, SULFATE ION, ... (7 entities in total) |
機能のキーワード | transcriptional coactivator, histone h3 modifications, e3 protein-ubiquitin ligase activity, structural genomics, structural genomics consortium, sgc, ligase |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Nucleus : O15164 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 44076.80 |
構造登録者 | Tallant, C.,Structural Genomics Consortium (SGC),Clark, P.G.K.,Vieira, L.C.C.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Fedorov, O.,Dixon, D.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S. (登録日: 2015-05-10, 公開日: 2015-06-17, 最終更新日: 2024-01-10) |
主引用文献 | Clark, P.G.,Vieira, L.C.,Tallant, C.,Fedorov, O.,Singleton, D.C.,Rogers, C.M.,Monteiro, O.P.,Bennett, J.M.,Baronio, R.,Muller, S.,Daniels, D.L.,Mendez, J.,Knapp, S.,Brennan, P.E.,Dixon, D.J. Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide inhibitor To Be Published, |
実験手法 | X-RAY DIFFRACTION (1.79 Å) |
構造検証レポート
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