4ZO1

Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha

Summary for 4ZO1

Entry DOI	10.2210/pdb4zo1/pdb
Descriptor	Thyroid hormone receptor beta, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha, ... (4 entities in total)
Functional Keywords	nuclear receptor, transcription factor, ligand binding, protein-ligand complex, protein binding
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: P10828 P19793
Total number of polymer chains	3
Total formula weight	55562.81
Authors	Bruning, J.B.,Kojetin, D.J.,Matta-Camacho, E.,Hughes, T.S.,Srinivasan, S.,Nwachukwu, J.C.,Cavett, V.,Nowak, J.,Chalmers, M.J.,Marciano, D.P.,Kamenecka, T.M.,Rance, M.,Shulman, A.I.,Mangelsdorf, D.J.,Griffin, P.R.,Nettles, K.W. (deposition date: 2015-05-05, release date: 2015-09-02, Last modification date: 2023-11-15)
Primary citation	Kojetin, D.J.,Matta-Camacho, E.,Hughes, T.S.,Srinivasan, S.,Nwachukwu, J.C.,Cavett, V.,Nowak, J.,Chalmers, M.J.,Marciano, D.P.,Kamenecka, T.M.,Shulman, A.I.,Rance, M.,Griffin, P.R.,Bruning, J.B.,Nettles, K.W. Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nat Commun, 6:8013-8013, 2015 Cited by PubMed: 26289479 DOI: 10.1038/ncomms9013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.221 Å)

Structure validation