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4ZHM

The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4

Summary for 4ZHM
Entry DOI10.2210/pdb4zhm/pdb
Descriptormupain-1-16-IG, Urokinase-type plasminogen activator, piperidine-1-carboximidamide, ... (4 entities in total)
Functional Keywordspeptides inhibitor, upa, serine protease, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase
Biological sourceHomo sapiens (Human)
More
Cellular locationSecreted: P00749
Total number of polymer chains2
Total formula weight29044.14
Authors
Jiang, L.,Andreasen, P.A.,Huang, M. (deposition date: 2015-04-25, release date: 2015-09-16, Last modification date: 2015-10-14)
Primary citationSrensen, H.P.,Xu, P.,Jiang, L.,Kromann-Hansen, T.,Jensen, K.J.,Huang, M.,Andreasen, P.A.
Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions.
J.Mol.Biol., 427:3110-3122, 2015
Cited by
PubMed: 26281711
DOI: 10.1016/j.jmb.2015.08.005
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

數據於2024-03-27公開中

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