4ZBF

Mcl-1 complexed with small molecules

Summary for 4ZBF

Entry DOI	10.2210/pdb4zbf/pdb
Related	4ZBI
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, (1R)-7-[3-(naphthalen-1-yloxy)propyl]-3,4-dihydro-2H-[1,4]thiazepino[2,3,4-hi]indole-6-carboxylic acid 1-oxide (3 entities in total)
Functional Keywords	inhibitor, complex, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	12
Total formula weight	219405.60
Authors	Zhao, B. (deposition date: 2015-04-14, release date: 2015-04-29, Last modification date: 2024-03-06)
Primary citation	Burke, J.P.,Bian, Z.,Shaw, S.,Zhao, B.,Goodwin, C.M.,Belmar, J.,Browning, C.F.,Vigil, D.,Friberg, A.,Camper, D.V.,Rossanese, O.W.,Lee, T.,Olejniczak, E.T.,Fesik, S.W. Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design. J.Med.Chem., 58:3794-3805, 2015 Cited by PubMed: 25844895 DOI: 10.1021/jm501984f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation