4YHO
Reversal Agent for Dabigatran
Summary for 4YHO
| Entry DOI | 10.2210/pdb4yho/pdb |
| Descriptor | aDabi-Fab3 heavy chain, aDabi-Fab3 light chain, N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, ... (4 entities in total) |
| Functional Keywords | antibody, dabigatran, pradaxa, antidote, reversal agent, immune system |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 2 |
| Total formula weight | 48355.96 |
| Authors | Schiele, F.,Nar, H. (deposition date: 2015-02-27, release date: 2016-01-13, Last modification date: 2024-01-10) |
| Primary citation | Schiele, F.,van Ryn, J.,Litzenburger, T.,Ritter, M.,Seeliger, D.,Nar, H. Structure-guided residence time optimization of a dabigatran reversal agent. Mabs, 7:871-880, 2015 Cited by PubMed: 26047352DOI: 10.1080/19420862.2015.1057364 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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