4XLD

Crystal structure of the human PPARg-LBD/rosiglitazone complex obtained by dry co-crystallization and in situ diffraction

Summary for 4XLD

Entry DOI	10.2210/pdb4xld/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, FORMIC ACID, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... (4 entities in total)
Functional Keywords	nuclear receptor ligand screening, gene regulation
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P37231
Total number of polymer chains	1
Total formula weight	34155.52
Authors	Delfosse, V.,Guichou, J.-F. (deposition date: 2015-01-13, release date: 2015-08-12, Last modification date: 2024-01-10)
Primary citation	Gelin, M.,Delfosse, V.,Allemand, F.,Hoh, F.,Sallaz-Damaz, Y.,Pirocchi, M.,Bourguet, W.,Ferrer, J.L.,Labesse, G.,Guichou, J.F. Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71:1777-1787, 2015 Cited by PubMed: 26249358 DOI: 10.1107/S1399004715010342 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation