4X9R

PLK-1 polo-box domain in complex with Bioactive Imidazolium-containing phosphopeptide macrocycle 3B

4X9R の概要

• エントリーDOI: 10.2210/pdb4x9r/pdb
• 関連するPDBエントリー: 4X9V 4X9W 4o6w
• 分子名称: Serine/threonine-protein kinase PLK1, Phosphopeptide macrocycle 3B (3 entities in total)
• 機能のキーワード: polo box domain phosphopeptide macrocycle inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28247.26

構造登録者

Grant, R.A.,Qian, W.-J.,Yaffe, M.B.,Burke, T.R. (登録日: 2014-12-11, 公開日: 2015-07-29, 最終更新日: 2023-11-15)

主引用文献

Qian, W.J.,Park, J.E.,Grant, R.,Lai, C.C.,Kelley, J.A.,Yaffe, M.B.,Lee, K.S.,Burke, T.R.
Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Biopolymers, 104:663-673, 2015

PubMed Abstract: Our recently discovered, selective, on-resin route to N(τ)-alkylated imidazolium-containing histidine residues affords new strategies for peptide mimetic design. In this, we demonstrate the use of this chemistry to prepare a series of macrocyclic phosphopeptides, in which imidazolium groups serve as ring-forming junctions. Interestingly, these cationic moieties subsequently serve to charge-mask the phosphoamino acid group that directed their formation. Neighbor-directed histidine N(τ)-alkylation opens the door to new families of phosphopeptidomimetics for use in a range of chemical biology contexts.

PubMed: 26152807
DOI: 10.1002/bip.22698

実験手法

X-RAY DIFFRACTION (1.398 Å)