4WYM

Structural basis of HIV-1 capsid recognition by CPSF6

Summary for 4WYM

• Entry DOI: 10.2210/pdb4wym/pdb
• Related: 4QNB
• Descriptor: Capsid protein p24, ISOFORM 2 OF CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 (2 entities in total)
• Functional Keywords: capsid protein, hexamer, engineered disulfide bonds, viral protein, cpsf6, viral restriction
• Biological source: Human immunodeficiency virus type 1 group M subtype B (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497; Nucleus : Q16630
• Total number of polymer chains: 23
• Total formula weight: 324333.72

Authors

Battacharya, A.,Taylor, A.B.,Hart, P.J.,Ivanov, D.N. (deposition date: 2014-11-17, release date: 2014-12-17, Last modification date: 2023-09-27)

• Primary citation: Bhattacharya, A.,Alam, S.L.,Fricke, T.,Zadrozny, K.,Sedzicki, J.,Taylor, A.B.,Demeler, B.,Pornillos, O.,Ganser-Pornillos, B.K.,Diaz-Griffero, F.,Ivanov, D.N.,Yeager, M.; Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.; Proc.Natl.Acad.Sci.USA, 111:18625-18630, 2014; PubMed: 25518861; DOI: 10.1073/pnas.1419945112

Experimental method

X-RAY DIFFRACTION (2.6 Å)