4WWW

Crystal structure of the E. coli ribosome bound to CEM-101

This is a non-PDB format compatible entry.

Replaces:  4V80Replaces:  1VT2Replaces:  3OR9Replaces:  3ORAReplaces:  3ORB

Summary for 4WWW

• Entry DOI: 10.2210/pdb4www/pdb
• Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... (56 entities in total)
• Functional Keywords: ribosomes, 70s, macrolide, ketolide, ribosome-antibiotic complex, ribosome/antibiotic
• Biological source: Escherichia coli str. K-12 substr. MG1655; More
• Total number of polymer chains: 104
• Total formula weight: 4237893.94

Authors

Dunkle, J.A.,Zhang, W.,Cate, J.H.D.,Mankin, A.S. (deposition date: 2014-11-12, release date: 2014-12-24, Last modification date: 2023-09-27)

• Primary citation: Llano-Sotelo, B.,Dunkle, J.,Klepacki, D.,Zhang, W.,Fernandes, P.,Cate, J.H.,Mankin, A.S.; Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.; Antimicrob. Agents Chemother., 54:4961-4970, 2010; PubMed: 20855725; DOI: 10.1128/AAC.00860-10

Experimental method

X-RAY DIFFRACTION (3.1 Å)