4WV6

Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8

Summary for 4WV6

Entry DOI	10.2210/pdb4wv6/pdb
Descriptor	Importin subunit alpha-1, Transcription initiation factor TFIID subunit 8, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	nuclear import, armadillo repeats, nls, transport protein
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm : P52292 Nucleus : Q7Z7C8
Total number of polymer chains	3
Total formula weight	55077.77
Authors	Trowitzsch, S. (deposition date: 2014-11-04, release date: 2015-01-28, Last modification date: 2024-01-10)
Primary citation	Trowitzsch, S.,Viola, C.,Scheer, E.,Conic, S.,Chavant, V.,Fournier, M.,Papai, G.,Ebong, I.O.,Schaffitzel, C.,Zou, J.,Haffke, M.,Rappsilber, J.,Robinson, C.V.,Schultz, P.,Tora, L.,Berger, I. Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules. Nat Commun, 6:6011-6011, 2015 Cited by PubMed: 25586196 DOI: 10.1038/ncomms7011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation