4UXL
Structure of Human ROS1 Kinase Domain in Complex with PF-06463922
Summary for 4UXL
Entry DOI | 10.2210/pdb4uxl/pdb |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile (3 entities in total) |
Functional Keywords | transferase, inhibitor, ros |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 37420.90 |
Authors | McTigue, M.,Deng, Y.,Liu, W.,Brooun, A.,Stewart, A. (deposition date: 2014-08-25, release date: 2015-03-11, Last modification date: 2024-01-10) |
Primary citation | Zou, H.Y.,Li, Q.,Engstrom, L.D.,West, M.,Appleman, V.,Wong, K.A.,Mctigue, M.,Deng, Y.,Liu, W.,Brooun, A.,Timofeevski, S.,Mcdonnell, S.R.P.,Jiang, P.,Falk, M.D.,Lappin, P.B.,Affolter, T.,Nichols, T.,Hu, W.,Lam, J.,Johnson, T.W.,Smeal, T.,Charest, A.,Fantin, V.R. Pf-06463922 is a Potent and Selective Next-Generation Ros1/Alk Inhibitor Capable of Blocking Crizotinib-Resistant Ros1 Mutations. Proc.Natl.Acad.Sci.USA, 112:3493-, 2015 Cited by PubMed: 25733882DOI: 10.1073/PNAS.1420785112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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