4UV7

The complex structure of extracellular domain of EGFR and GC1118A

Summary for 4UV7

Entry DOI	10.2210/pdb4uv7/pdb
Descriptor	EPIDERMAL GROWTH FACTOR RECEPTOR, GC1118A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	transferase, receptor tyrosine kinase, antibody
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	3
Total formula weight	118519.41
Authors	Yoo, J.H.,Cho, H.S. (deposition date: 2014-08-05, release date: 2015-10-14, Last modification date: 2024-01-10)
Primary citation	Lim, Y.,Yoo, J.,Kim, M.S.,Hur, M.,Lee, E.H.,Hur, H.S.,Lee, J.C.,Lee, S.N.,Park, T.W.,Lee, K.,Chang, K.H.,Kim, K.,Kang, Y.,Hong, K.W.,Kim, S.H.,Kim, Y.G.,Yoon, Y.,Nam, D.H.,Yang, H.,Kim, D.G.,Cho, H.S.,Won, J. Gc1118, an Anti-Egfr Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity Against High-Affinity Egfr Ligands. Mol.Cancer Ther., 15:251-, 2016 Cited by PubMed: 26586721 DOI: 10.1158/1535-7163.MCT-15-0679 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation