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4URY

The crystal structure of H-Ras and SOS in complex with ligands

Summary for 4URY
Entry DOI10.2210/pdb4ury/pdb
Related4URU 4URV 4URW 4URX 4URZ 4US0 4US1 4US2
DescriptorGTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, N-[(4-aminophenyl)sulfonyl]cyclopropanecarboxamide, ... (4 entities in total)
Functional Keywordssignaling protein
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationCell membrane. Isoform 2: Nucleus: P01112
Total number of polymer chains2
Total formula weight78741.54
Authors
Primary citationWinter, J.,Anderson, M.,Blades, K.,Chresta, C.,Embrey, K.J.,Fairley, G.,Faulder, P.,Finlay, M.R.V.,Kettle, J.G.,Nowak, T.,Overman, R.,Patel, S.J.,Perkins, P.,Spadola, L.,Tart, J.,Tucker, J.A.,Wrigley, G.
Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58:2265-, 2015
Cited by
PubMed: 25695162
DOI: 10.1021/JM501660T
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.47 Å)
Structure validation

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