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4UMQ

Structure of MELK in complex with inhibitors

Summary for 4UMQ
Entry DOI10.2210/pdb4umq/pdb
Related4D2T 4D2V 4D2W 4UMP 4UMR 4UMT 4UMU
DescriptorMATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 3-{5-[(3-hydroxy-5-methoxyphenyl)amino]-2-(phenylcarbamoyl)phenoxy}propan-1-aminium (3 entities in total)
Functional Keywordstransferase, fragment based drug design
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane ; Peripheral membrane protein : Q14680
Total number of polymer chains1
Total formula weight41300.74
Authors
Primary citationJohnson, C.N.,Berdini, V.,Beke, L.,Bonnet, P.,Brehmer, D.,Coyle, J.E.,Day, P.J.,Frederickson, M.,Freyne, E.J.E.,Gilissen, R.A.H.J.,Hamlett, C.C.F.,Howard, S.,Meerpoel, L.,Mcmenamin, R.,Patel, S.,Rees, D.C.,Sharff, A.,Sommen, F.,Wu, T.,Linders, J.T.M.
Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6:25-, 2015
Cited by
PubMed: 25589925
DOI: 10.1021/ML5001245
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

數據於2024-03-27公開中

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