4UH3

Structure of rat neuronal nitric oxide synthase heme domain in complex with N1-(3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5- fluorophenyl)-N1,N2-dimethylethane-1,2-diamine

Summary for 4UH3

Entry DOI	10.2210/pdb4uh3/pdb
Related	4UGZ 4UH0 4UH1 4UH2 4UH4 4UH5 4UH6 4UH7 4UH8 4UH9 4UHA
Descriptor	NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	oxidoreductase, nitric oxide synthase, inhibitor complex
Biological source	RATTUS NORVEGICUS (NORWAY RAT)
Cellular location	Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains	2
Total formula weight	100156.85
Authors	Li, H.,Poulos, T.L. (deposition date: 2015-03-23, release date: 2015-07-15, Last modification date: 2015-08-05)
Primary citation	Kang, S.,Li, H.,Tang, W.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. 2-Aminopyridines with a Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. J.Med.Chem., 58:5548-, 2015 Cited by PubMed: 26120733 DOI: 10.1021/ACS.JMEDCHEM.5B00573 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation