4UBV

Structure of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis with an partially acetylated cysteine in complex with acetyl-CoA and CoA

Summary for 4UBV

• Entry DOI: 10.2210/pdb4ubv/pdb
• Descriptor: Acetyl-CoA acetyltransferase FadA5, ACETYL COENZYME *A, COENZYME A, ... (7 entities in total)
• Functional Keywords: partially acetylated degradative thiolase, acetyl-coa, coa, transferase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 89048.14

Authors

Schaefer, C.M.,Kisker, C. (deposition date: 2014-08-13, release date: 2014-12-17, Last modification date: 2023-12-20)

• Primary citation: Schaefer, C.M.,Lu, R.,Nesbitt, N.M.,Schiebel, J.,Sampson, N.S.,Kisker, C.; FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis.; Structure, 23:21-33, 2015; PubMed: 25482540; DOI: 10.1016/j.str.2014.10.010

Experimental method

X-RAY DIFFRACTION (1.95 Å)