4UB0

New design for monovalent bispecific IgG through cysteine engineering of the CH1-CL interface

Summary for 4UB0

• Entry DOI: 10.2210/pdb4ub0/pdb
• Descriptor: IgG1, heavy chain, IgG1, light chain (3 entities in total)
• Functional Keywords: fab, knobs-into-holes, bispecific, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 46847.18

Authors

Oganesyan, V.Y.,Dall'Acqua, W.F. (deposition date: 2014-08-11, release date: 2015-07-15, Last modification date: 2023-12-27)

• Primary citation: Mazor, Y.,Oganesyan, V.,Yang, C.,Hansen, A.,Wang, J.,Liu, H.,Sachsenmeier, K.,Carlson, M.,Gadre, D.V.,Borrok, M.J.,Yu, X.Q.,Dall'Acqua, W.,Wu, H.,Chowdhury, P.S.; Improving target cell specificity using a novel monovalent bispecific IgG design.; Mabs, 7:377-389, 2015; PubMed: 25621507; DOI: 10.1080/19420862.2015.1007816

Experimental method

X-RAY DIFFRACTION (2.2 Å)