4U6K
Crystal structure of DNA/RNA duplex containing 2'-4'-BNA-NC
Summary for 4U6K
Entry DOI | 10.2210/pdb4u6k/pdb |
Related | 4U6L 4U6M |
Descriptor | RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*G)-3'), DNA (5'-D(*(NCU)P*(NTT)P*CP*TP*TP*CP*TP*(NTT)P*(NCU))-3'), COBALT HEXAMMINE(III), ... (4 entities in total) |
Functional Keywords | dna/rna duplex, antisense, bridged nucleic acid, dna-rna complex, dna/rna |
Biological source | synthetic construct More |
Total number of polymer chains | 4 |
Total formula weight | 12225.13 |
Authors | Kondo, J.,Nomura, Y.,Kitahara, Y.,Obika, S.,Torigoe, H. (deposition date: 2014-07-29, release date: 2015-08-19, Last modification date: 2022-07-06) |
Primary citation | Kondo, J.,Nomura, Y.,Kitahara, Y.,Obika, S.,Torigoe, H. The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA. Chem.Commun.(Camb.), 52:2354-2357, 2016 Cited by PubMed: 26731288DOI: 10.1039/c5cc08300a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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