4TV3

Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design

Summary for 4TV3

Entry DOI	10.2210/pdb4tv3/pdb
Related	4TUU
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
Functional Keywords	lipid kinase activity, atpase activity, surface plasmon resonance (spr), isothermal titration calorimetry (itc)., transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	110408.57
Authors	Chen, P.,Deng, Y.-L.,Bergqvist, S.,Falk, M.,Liu, W.,Timofeevski, S. (deposition date: 2014-06-25, release date: 2014-08-06, Last modification date: 2023-12-27)
Primary citation	Chen, P.,Deng, Y.L.,Bergqvist, S.,Falk, M.D.,Liu, W.,Timofeevski, S.,Brooun, A. Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design. Protein Sci., 23:1332-1340, 2014 Cited by PubMed: 25043846 DOI: 10.1002/pro.2517 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation