4S1R

Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core

4S1R の概要

• エントリーDOI: 10.2210/pdb4s1r/pdb
• 関連するPDBエントリー: 4S1Q 4S1S
• 分子名称: clade A/E 93TH057 HIV-1 gp120 core, Fab of VRC01-lineage antibody,45-VRC01.H08.F-117225 heavy chain, Fab of VRC01 light chain, ... (4 entities in total)
• 機能のキーワード: hiv-1, neutralizing antibodies, vrc01-lineage, antibody maturation, evolutionary rate, viral protein-immune system-inhibitor complex, viral protein/immune system/inhibitor
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 89851.62

構造登録者

Kwon, Y.D.,Yang, Y.,Zhang, B.,Kwong, P.D. (登録日: 2015-01-14, 公開日: 2015-04-22, 最終更新日: 2023-09-20)

• 主引用文献: Wu, X.,Zhang, Z.,Schramm, C.A.,Joyce, M.G.,Do Kwon, Y.,Zhou, T.,Sheng, Z.,Zhang, B.,O'Dell, S.,McKee, K.,Georgiev, I.S.,Chuang, G.Y.,Longo, N.S.,Lynch, R.M.,Saunders, K.O.,Soto, C.,Srivatsan, S.,Yang, Y.,Bailer, R.T.,Louder, M.K.,Mullikin, J.C.,Connors, M.,Kwong, P.D.,Mascola, J.R.,Shapiro, L.; Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.; Cell(Cambridge,Mass.), 161:470-485, 2015; PubMed: 25865483; DOI: 10.1016/j.cell.2015.03.004

実験手法

X-RAY DIFFRACTION (3.214 Å)