4S14

Crystal structure of the orphan nuclear receptor RORgamma ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)

Summary for 4S14

• Entry DOI: 10.2210/pdb4s14/pdb
• Related: 4S15
• Descriptor: Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid (3 entities in total)
• Functional Keywords: transcription factor, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P51449 P48552
• Total number of polymer chains: 2
• Total formula weight: 31736.84

Authors

Huang, P.,Santori, F.R.,Littman, D.R.,Rastinejad, F. (deposition date: 2015-01-07, release date: 2015-02-11, Last modification date: 2015-02-25)

• Primary citation: Santori, F.R.,Huang, P.,van de Pavert, S.A.,Douglass, E.F.,Leaver, D.J.,Haubrich, B.A.,Keber, R.,Lorbek, G.,Konijn, T.,Rosales, B.N.,Rozman, D.,Horvat, S.,Rahier, A.,Mebius, R.E.,Rastinejad, F.,Nes, W.D.,Littman, D.R.; Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells.; Cell Metab, 21:286-297, 2015; PubMed: 25651181; DOI: 10.1016/j.cmet.2015.01.004

Experimental method

X-RAY DIFFRACTION (3.542 Å)