4RYD

X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba

Summary for 4RYD

• Entry DOI: 10.2210/pdb4ryd/pdb
• Related: 1P8J 4OMC 4OMD
• Related PRD ID: PRD_001257
• Descriptor: Furin, para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total)
• Functional Keywords: competitive inhibitor, pro-protein convertase, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958
• Total number of polymer chains: 12
• Total formula weight: 320519.12

Authors

Dahms, S.O.,Than, M.E. (deposition date: 2014-12-15, release date: 2015-05-27, Last modification date: 2015-07-15)

• Primary citation: Hardes, K.,Becker, G.L.,Lu, Y.,Dahms, S.O.,Kohler, S.,Beyer, W.,Sandvig, K.,Yamamoto, H.,Lindberg, I.,Walz, L.,von Messling, V.,Than, M.E.,Garten, W.,Steinmetzer, T.; Novel Furin Inhibitors with Potent Anti-infectious Activity.; Chemmedchem, 10:1218-1231, 2015; PubMed: 25974265; DOI: 10.1002/cmdc.201500103

Experimental method

X-RAY DIFFRACTION (2.15 Å)