4RX4

Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 8ANC134 in complex with HIV-1 clade A Q842.d12 gp120

Summary for 4RX4

• Entry DOI: 10.2210/pdb4rx4/pdb
• Related: 4RWY
• Descriptor: HIV-1 Clade A Q842.d12 gp120, 8ANC134 Heavy chain, 8ANC134 Light Chain, ... (6 entities in total)
• Functional Keywords: hiv-1 attachment protein, broadly neutralizing antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1 (11676); More
• Total number of polymer chains: 6
• Total formula weight: 178981.49

Authors

Zhou, T.,Acharya, P.,Moquin, S.,Kwong, P.D. (deposition date: 2014-12-08, release date: 2015-07-01, Last modification date: 2021-06-02)

• Primary citation: Zhou, T.,Lynch, R.M.,Chen, L.,Acharya, P.,Wu, X.,Doria-Rose, N.A.,Joyce, M.G.,Lingwood, D.,Soto, C.,Bailer, R.T.,Ernandes, M.J.,Kong, R.,Longo, N.S.,Louder, M.K.,McKee, K.,O'Dell, S.,Schmidt, S.D.,Tran, L.,Yang, Z.,Druz, A.,Luongo, T.S.,Moquin, S.,Srivatsan, S.,Yang, Y.,Zhang, B.,Zheng, A.,Pancera, M.,Kirys, T.,Georgiev, I.S.,Gindin, T.,Peng, H.P.,Yang, A.S.,Mullikin, J.C.,Gray, M.D.,Stamatatos, L.,Burton, D.R.,Koff, W.C.,Cohen, M.S.,Haynes, B.F.,Casazza, J.P.,Connors, M.,Corti, D.,Lanzavecchia, A.,Sattentau, Q.J.,Weiss, R.A.,West, A.P.,Bjorkman, P.J.,Scheid, J.F.,Nussenzweig, M.C.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.; Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.; Cell(Cambridge,Mass.), 161:1280-1292, 2015; PubMed: 26004070; DOI: 10.1016/j.cell.2015.05.007

Experimental method

X-RAY DIFFRACTION (3.45 Å)