4RPT

The 1.35A structure of a viral RNase L antagonist reveals basis for the 2'-5'-oligoadenylate binding and enzyme activity.

Summary for 4RPT

• Entry DOI: 10.2210/pdb4rpt/pdb
• Related: 4YE2
• Descriptor: Capping enzyme protein, MALONATE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: 2h phosphodiesterase, viral protein
• Biological source: Rotavirus A
• Cellular location: Virion : B3F2X4
• Total number of polymer chains: 2
• Total formula weight: 33861.19

Authors

Hu, L.,Prasad, B.V.V. (deposition date: 2014-10-31, release date: 2015-04-29, Last modification date: 2024-02-28)

• Primary citation: Ogden, K.M.,Hu, L.,Jha, B.K.,Sankaran, B.,Weiss, S.R.,Silverman, R.H.,Patton, J.T.,Prasad, B.V.; Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.; J.Virol., 89:6633-6645, 2015; PubMed: 25878106; DOI: 10.1128/JVI.00701-15

Experimental method

X-RAY DIFFRACTION (1.35 Å)