4RP6

Structure of the amyloid-forming segment LTIITLE from p53 (residues 252-258)

Summary for 4RP6

• Entry DOI: 10.2210/pdb4rp6/pdb
• Related: 4RP7
• Descriptor: LTIITLE heptapeptide segment from p53 (2 entities in total)
• Functional Keywords: p53, amyloid, fibril, amyloid-like protofibril, p53 aggregates, polymer, transcription factor, oncogene, cancer, p53 mutant, protein fibril
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 1
• Total formula weight: 801.97

Authors

Soriaga, A.B.,Soragni, A.,Eisenberg, D. (deposition date: 2014-10-29, release date: 2016-01-13, Last modification date: 2024-02-28)

• Primary citation: Soragni, A.,Janzen, D.M.,Johnson, L.M.,Lindgren, A.G.,Thai-Quynh Nguyen, A.,Tiourin, E.,Soriaga, A.B.,Lu, J.,Jiang, L.,Faull, K.F.,Pellegrini, M.,Memarzadeh, S.,Eisenberg, D.S.; A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.; Cancer Cell, 29:90-103, 2016; PubMed: 26748848; DOI: 10.1016/j.ccell.2015.12.002

Experimental method

X-RAY DIFFRACTION (1.703 Å)