4RJD

TFP bound in alternate orientations to calcium-saturated Calmodulin C-Domains

Summary for 4RJD

• Entry DOI: 10.2210/pdb4rjd/pdb
• Related: 1A29 1CTR 1LIN
• Descriptor: Calmodulin, CALCIUM ION, 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, ... (8 entities in total)
• Functional Keywords: anti-psychotic, antagonist, ca2+ binding, central nervous system, trifluoromethyl, promiscuous binding, tfp-binding, calcium-binding protein
• Biological source: Rattus norvegicus (brown rat,rat,rats)
• Total number of polymer chains: 2
• Total formula weight: 17462.16

Authors

Feldkamp, M.D.,Gakhar, L.,Pandey, N.,Shea, M.A. (deposition date: 2014-10-08, release date: 2015-08-26, Last modification date: 2023-09-20)

• Primary citation: Feldkamp, M.D.,Gakhar, L.,Pandey, N.,Shea, M.A.; Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin.; Proteins, 83:989-996, 2015; PubMed: 25694384; DOI: 10.1002/prot.24781

Experimental method

X-RAY DIFFRACTION (2 Å)