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4R4T

Crystal Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)phenylthioamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid

Summary for 4R4T
Entry DOI10.2210/pdb4r4t/pdb
Related4R4C 4R4I 4R4O 4R4Q
DescriptorReplication protein A 70 kDa DNA-binding subunit, 5-{4-[({[4-(5-carboxyfuran-2-yl)phenyl]carbonothioyl}amino)methyl]phenyl}-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid (3 entities in total)
Functional Keywordsob-fold, protein-protein interaction, protein binding
Biological sourceHomo sapiens (human)
Cellular locationNucleus : P27694
Total number of polymer chains1
Total formula weight14090.18
Authors
Feldkamp, M.D.,Waterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Frank, A.O.,Vangamudi, B.,Sousa-Fagundes, E.M.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2014-08-19, release date: 2014-11-19, Last modification date: 2023-09-20)
Primary citationWaterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Feldkamp, M.D.,Frank, A.O.,Vangamudi, B.,Souza-Fagundes, E.M.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W.
Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6:140-145, 2015
Cited by
PubMed: 25699140
DOI: 10.1021/ml5003629
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.28 Å)
Structure validation

217705

數據於2024-03-27公開中

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