4R18

Ligand-induced Lys33-Thr1 crosslinking at subunit beta5 of the yeast 20S proteasome

4R18 の概要

• エントリーDOI: 10.2210/pdb4r18/pdb
• 関連するPDBエントリー: 1RYP 4R17
• 分子名称: PROTEASOME SUBUNIT ALPHA TYPE-2, PROTEASOME SUBUNIT BETA TYPE-4, PROTEASOME SUBUNIT BETA TYPE-5, ... (17 entities in total)
• 機能のキーワード: proteasome, drug development, binding analysis, umpolung, crosslink, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Saccharomyces cerevisiae S288c (Baker's yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 731524.37

構造登録者

Dubiella, C.,Cui, H.,Gersch, M.,Brouwer, A.J.,Sieber, S.A.,Krueger, A.,Liskamp, R.,Groll, M. (登録日: 2014-08-04, 公開日: 2014-10-15, 最終更新日: 2023-12-06)

• 主引用文献: Dubiella, C.,Cui, H.,Gersch, M.,Brouwer, A.J.,Sieber, S.A.,Kruger, A.,Liskamp, R.M.,Groll, M.; Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.; Angew.Chem.Int.Ed.Engl., 53:11969-11973, 2014; PubMed: 25244435; DOI: 10.1002/anie.201406964

実験手法

X-RAY DIFFRACTION (2.4 Å)