4R17

Ligand-induced aziridine-formation at subunit beta5 of the yeast 20S proteasome

Summary for 4R17

• Entry DOI: 10.2210/pdb4r17/pdb
• Related: 1RYP 4R18
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total)
• Functional Keywords: proteasome, drug development, binding analysis, umpolung, crosslink, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae S288c (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 731520.33

Authors

Dubiella, C.,Cui, H.,Gersch, M.,Brouwer, A.J.,Sieber, S.A.,Krueger, A.,Liskamp, R.,Groll, M. (deposition date: 2014-08-04, release date: 2014-10-15, Last modification date: 2023-09-20)

• Primary citation: Dubiella, C.,Cui, H.,Gersch, M.,Brouwer, A.J.,Sieber, S.A.,Kruger, A.,Liskamp, R.M.,Groll, M.; Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.; Angew.Chem.Int.Ed.Engl., 53:11969-11973, 2014; PubMed: 25244435; DOI: 10.1002/anie.201406964

Experimental method

X-RAY DIFFRACTION (2.1 Å)