4R12

Crystal structure of the gamma-secretase component Nicastrin

Summary for 4R12

• Entry DOI: 10.2210/pdb4r12/pdb
• Descriptor: Putative uncharacterized protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: alpha/beta, nicastrin, putative substrate-recruiting component, gamma-secretase complex, protein binding
• Biological source: Dictyostelium purpureum (Slime mold)
• Total number of polymer chains: 1
• Total formula weight: 68440.68

Authors

Xie, T.,Yan, C.,Zhou, R.,Zhao, Y.,Sun, L.,Yang, G.,Lu, P.,Ma, D.,Shi, Y. (deposition date: 2014-08-03, release date: 2014-09-17, Last modification date: 2023-11-08)

• Primary citation: Xie, T.,Yan, C.,Zhou, R.,Zhao, Y.,Sun, L.,Yang, G.,Lu, P.,Ma, D.,Shi, Y.; Crystal structure of the gamma-secretase component nicastrin.; Proc.Natl.Acad.Sci.USA, 111:13349-13354, 2014; PubMed: 25197054; DOI: 10.1073/pnas.1414837111

Experimental method

X-RAY DIFFRACTION (1.95 Å)