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4QWU

yCP beta5-C52F mutant in complex with bortezomib

Summary for 4QWU
Entry DOI10.2210/pdb4qwu/pdb
Related1RYP 4QTR 4QUX 4QUY 4QV0 4QV1 4QV3 4QV4 4QV5 4QV6 4QV7 4QV8 4QV9 4QVL 4QVM 4QVN 4QVP 4QVQ 4QWR 4QWS 4QWX 4QZ0 4QZ1 4QZ2 4QZ3 4QZ4 4QZ5 4QZ6 4QZX 4QZZ
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
Functional Keywordscancer, proteasome, bortezomib, drug resistance, binding analysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
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Cellular locationCytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains28
Total formula weight733756.20
Authors
Huber, E.M.,Heinemeyer, W.,Groll, M. (deposition date: 2014-07-17, release date: 2015-02-04, Last modification date: 2023-09-20)
Primary citationHuber, E.M.,Heinemeyer, W.,Groll, M.
Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.
Structure, 23:407-417, 2015
Cited by
PubMed: 25599643
DOI: 10.1016/j.str.2014.11.019
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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