4QTC

Structure of human haspin (GSG2) in complex with SCH772984 revealing the first type-I binding mode

Summary for 4QTC

Entry DOI	10.2210/pdb4qtc/pdb
Related	4QTA 4QTB 4QTD 4QTE
Descriptor	Serine/threonine-protein kinase haspin, (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, ... (5 entities in total)
Functional Keywords	structural genomics, structural genomics consortium, sgc, transferase, kinase, inhibitor, allosteric, structural genomics consortium (sgc), transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q8TF76
Total number of polymer chains	1
Total formula weight	41601.52
Authors	Chaikuad, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-07-07, release date: 2014-07-23, Last modification date: 2023-09-20)
Primary citation	Chaikuad, A.,M C Tacconi, E.,Zimmer, J.,Liang, Y.,Gray, N.S.,Tarsounas, M.,Knapp, S. A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics. Nat.Chem.Biol., 10:853-860, 2014 Cited by PubMed: 25195011 DOI: 10.1038/nchembio.1629 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation