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4QOC

crystal structure of compound 16 bound to MDM2(17-111), {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID

Summary for 4QOC
Entry DOI10.2210/pdb4qoc/pdb
Related4QO4
DescriptorE3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-(pyrrolidin-1-ylsulfonyl)ethyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid (3 entities in total)
Functional Keywordsmdm2, p53, protein-protein interaction, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains6
Total formula weight70497.68
Authors
Huang, X. (deposition date: 2014-06-19, release date: 2015-05-06, Last modification date: 2024-02-28)
Primary citationWang, Y.,Zhu, J.,Liu, J.J.,Chen, X.,Mihalic, J.,Deignan, J.,Yu, M.,Sun, D.,Kayser, F.,McGee, L.R.,Lo, M.C.,Chen, A.,Zhou, J.,Ye, Q.,Huang, X.,Long, A.M.,Yakowec, P.,Oliner, J.D.,Olson, S.H.,Medina, J.C.
Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Bioorg.Med.Chem.Lett., 24:3782-3785, 2014
Cited by
PubMed: 25042256
DOI: 10.1016/j.bmcl.2014.06.073
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

數據於2024-03-27公開中

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