4QNB

Disulfide stabilized HIV-1 CA hexamer in complex with PHENYL-L-PHENYLALANINAMIDE inhibitor

Summary for 4QNB

• Entry DOI: 10.2210/pdb4qnb/pdb
• Related: 3h47
• Descriptor: CAPSID PROTEIN P24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE (3 entities in total)
• Functional Keywords: capsid protein, disulfide crosslink, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) (HIV-1)
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497
• Total number of polymer chains: 1
• Total formula weight: 25886.79

Authors

Pornillos, O. (deposition date: 2014-06-17, release date: 2014-12-31, Last modification date: 2023-09-20)

• Primary citation: Bhattacharya, A.,Alam, S.L.,Fricke, T.,Zadrozny, K.,Sedzicki, J.,Taylor, A.B.,Demeler, B.,Pornillos, O.,Ganser-Pornillos, B.K.,Diaz-Griffero, F.,Ivanov, D.N.,Yeager, M.; Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.; Proc.Natl.Acad.Sci.USA, 111:18625-18630, 2014; PubMed: 25518861; DOI: 10.1073/pnas.1419945112

Experimental method

X-RAY DIFFRACTION (1.996 Å)