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4QLT

yCP in complex with tripeptidic epoxyketone inhibitor 2 (PR924)

Summary for 4QLT
Entry DOI10.2210/pdb4qlt/pdb
Related1G65 1RYP 4QLQ 4QLS 4QLU 4QLV
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
Functional Keywordsproteasome, epoxyketone, immunoproteasome inhibitor, binding analysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
More
Cellular locationCytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains28
Total formula weight732877.16
Authors
de Bruin, G.,Huber, E.,Xin, B.,van Rooden, E.,Al-Ayed, K.,Kim, K.,Kisselev, A.,Driessen, C.,van der Marel, G.,Groll, M.,Overkleeft, H. (deposition date: 2014-06-13, release date: 2014-07-23, Last modification date: 2023-11-08)
Primary citationDe Bruin, G.,Huber, E.M.,Xin, B.T.,Van Rooden, E.J.,Al-Ayed, K.,Kim, K.B.,Kisselev, A.F.,Driessen, C.,Van der Stelt, M.,Van der Marel, G.A.,Groll, M.,Overkleeft, H.S.
Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57:6197-6209, 2014
Cited by
PubMed: 25006746
DOI: 10.1021/jm500716s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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