4QGW

Crystal sturcture of the R132K:R111L:L121D mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.77 angstrom resolution

4QGW の概要

• エントリーDOI: 10.2210/pdb4qgw/pdb
• 関連するPDBエントリー: 2G7B 3F8A 3FEP 4EEJ 4EXZ 4I9R 4QGV 4QGX
• 分子名称: Cellular retinoic acid-binding protein 2, (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: protein engineering, protein fluorescence, merocyanine dyes for fluorescent protein labeling, fluorescent protein tag, merocyanine protonated schiff base iminium, protein binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P29373
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31573.07

構造登録者

Nosrati, M.,Yapici, I.,Geiger, J.H. (登録日: 2014-05-26, 公開日: 2015-01-28, 最終更新日: 2015-02-11)

• 主引用文献: Yapici, I.,Lee, K.S.,Berbasova, T.,Nosrati, M.,Jia, X.,Vasileiou, C.,Wang, W.,Santos, E.M.,Geiger, J.H.,Borhan, B.; "Turn-on" protein fluorescence: in situ formation of cyanine dyes.; J.Am.Chem.Soc., 137:1073-1080, 2015; PubMed: 25534273; DOI: 10.1021/ja506376j

実験手法

X-RAY DIFFRACTION (1.77 Å)