Crystal sturcture of the R132K:R111L mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.73 angstrom resolution.

Summary for 4QGV

Related3FEP 4I9S 4EXZ 2G7B 3F8A 4EEJ 4QGW 4QGX
DescriptorCellular retinoic acid-binding protein 2, (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal (3 entities in total)
Functional Keywordsprotein engineering, protein fluorescence merocyanine dyes for fluorescent protein labeling, fluorescent protein tag, merocyanine protonated schiff base, iminium, protein binding
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P29373
Total number of polymer chains2
Total molecular weight31286.87
Nosrati, M.,Yapici, I.,Geiger, J.H. (deposition date: 2014-05-25, release date: 2015-01-28, Last modification date: 2017-11-22)
Primary citation
Yapici, I.,Lee, K.S.,Berbasova, T.,Nosrati, M.,Jia, X.,Vasileiou, C.,Wang, W.,Santos, E.M.,Geiger, J.H.,Borhan, B.
"Turn-on" protein fluorescence: in situ formation of cyanine dyes.
J.Am.Chem.Soc., 137:1073-1080, 2015
PubMed: 25534273 (PDB entries with the same primary citation)
DOI: 10.1021/ja506376j
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23370.4%5.4%6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution