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4QG2

Crystal structure of the tetrameric GTP/dATP/ATP-bound SAMHD1 (RN206) mutant catalytic core

Summary for 4QG2
Entry DOI10.2210/pdb4qg2/pdb
Related4BZB 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG4
DescriptorDeoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordsdeoxynucleoside triphosphate triphosphohydrolase, 2'-deoxyadenosine-5'-triphosphate, guanosine-5'-triphosphate, hiv restriction factor, dntpase, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationNucleus : Q9Y3Z3
Total number of polymer chains4
Total formula weight257860.17
Authors
Koharudin, L.M.I.,Wu, Y.,DeLucia, M.,Mehrens, J.,Gronenborn, A.M.,Ahn, J. (deposition date: 2014-05-22, release date: 2014-10-15, Last modification date: 2023-09-20)
Primary citationKoharudin, L.M.,Wu, Y.,DeLucia, M.,Mehrens, J.,Gronenborn, A.M.,Ahn, J.
Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.
J.Biol.Chem., 289:32617-32627, 2014
Cited by
PubMed: 25288794
DOI: 10.1074/jbc.M114.591958
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

217705

數據於2024-03-27公開中

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