4QBM

Crystal structure of human BAZ2A bromodomain in complex with a diacetylated histone 4 peptide (H4K16acK20ac)

Summary for 4QBM

Entry DOI	10.2210/pdb4qbm/pdb
Related	4QC1 4QC3
Descriptor	Bromodomain adjacent to zinc finger domain protein 2A, histone H4 peptide with sequence Gly-Ala-Lys(ac)-Arg-His-Arg-Lys(ac)-Val-Leu, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bromodomain adjacent to zinc finger domain protein 2a, transcription termination factor i-interacting protein 5, tip5, bromodomain, structural genomics consortium, sgc, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleolus : Q9UIF9
Total number of polymer chains	4
Total formula weight	27382.93
Authors	Tallant, C.,Nunez-Alonso, G.,Picaud, S.,Filippakopoulos, P.,Krojer, T.,Williams, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-05-08, release date: 2014-05-21, Last modification date: 2023-12-06)
Primary citation	Tallant, C.,Valentini, E.,Fedorov, O.,Overvoorde, L.,Ferguson, F.M.,Filippakopoulos, P.,Svergun, D.I.,Knapp, S.,Ciulli, A. Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. Structure, 23:80-92, 2015 Cited by PubMed: 25533489 DOI: 10.1016/j.str.2014.10.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation