4Q9J

P-glycoprotein cocrystallised with QZ-Val

Summary for 4Q9J

• Entry DOI: 10.2210/pdb4q9j/pdb
• Related: 4Q9H 4Q9I 4Q9K 4Q9L
• Related PRD ID: PRD_001235
• Descriptor: Multidrug resistance protein 1A, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID (2 entities in total)
• Functional Keywords: membrane protein, transporter, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mus musculus (mouse)
• Cellular location: Cell membrane; Multi-pass membrane protein: P21447
• Total number of polymer chains: 4
• Total formula weight: 144198.37

Authors

McGrath, A.P.,Szewczyk, P.,Chang, G. (deposition date: 2014-05-01, release date: 2015-03-04, Last modification date: 2023-11-15)

• Primary citation: Szewczyk, P.,Tao, H.,McGrath, A.P.,Villaluz, M.,Rees, S.D.,Lee, S.C.,Doshi, R.,Urbatsch, I.L.,Zhang, Q.,Chang, G.; Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.; Acta Crystallogr.,Sect.D, 71:732-741, 2015; PubMed: 25760620; DOI: 10.1107/S1399004715000978

Experimental method

X-RAY DIFFRACTION (3.6 Å)