4Q5M

D30N tethered HIV-1 protease dimer/saquinavir complex

Summary for 4Q5M

Entry DOI	10.2210/pdb4q5m/pdb
Related PRD ID	PRD_000454
Descriptor	Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (HIV-1) More
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains	1
Total formula weight	22571.63
Authors	Prashar, V.,Bihani, S.C.,Ferrer, J.L.,Hosur, M.V. (deposition date: 2014-04-17, release date: 2015-04-08, Last modification date: 2023-11-08)
Primary citation	Prashar, V.,Bihani, S.C.,Ferrer, J.L.,Hosur, M.V. Structural Basis of Why Nelfinavir-Resistant D30N Mutant of HIV-1 Protease Remains Susceptible to Saquinavir. Chem.Biol.Drug Des., 86:302-308, 2015 Cited by PubMed: 25487655 DOI: 10.1111/cbdd.12494 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.795 Å)

Structure validation