4Q4F

Crystal structure of LIMP-2 (space group C2)

Summary for 4Q4F

• Entry DOI: 10.2210/pdb4q4f/pdb
• Related: 4Q4B
• Descriptor: Lysosome membrane protein 2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: lysosomal targeting, beta-glucocerebrosidase, ci-mpr, er, endosome, lysosome, cell adhesion
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome membrane; Multi-pass membrane protein: Q14108
• Total number of polymer chains: 1
• Total formula weight: 53426.26

Authors

Zhao, Y.,Ren, J.,Padilla-Parra, S.,Fry, L.E.,Stuart, D.I. (deposition date: 2014-04-14, release date: 2014-07-30, Last modification date: 2023-09-20)

• Primary citation: Zhao, Y.,Ren, J.,Padilla-Parra, S.,Fry, E.E.,Stuart, D.I.; Lysosome sorting of beta-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.; Nat Commun, 5:4321-4321, 2014; PubMed: 25027712; DOI: 10.1038/ncomms5321

Experimental method

X-RAY DIFFRACTION (2.8 Å)