4Q21

MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS

Summary for 4Q21

Entry DOI	10.2210/pdb4q21/pdb
Descriptor	C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	oncogene protein
Biological source	Homo sapiens (human)
Cellular location	Cell membrane. Isoform 2: Nucleus: P01112
Total number of polymer chains	1
Total formula weight	21791.65
Authors	Kim, S.-H. (deposition date: 1991-09-25, release date: 1992-07-15, Last modification date: 2024-02-28)
Primary citation	Milburn, M.V.,Tong, L.,deVos, A.M.,Brunger, A.,Yamaizumi, Z.,Nishimura, S.,Kim, S.H. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247:939-945, 1990 Cited by PubMed: 2406906 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation